![]() With the simultaneous use of metoclopramide may increase absorption of Paralife and its increased concentration in blood plasma. In applying cholestyramine a period of less than 1 h after administration of Paralife may decrease of its absorption.Īt simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body. Cases of hepatotoxicity, while the use of Paralife and phenobarbital. When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Paralife, which is caused by an increase in its metabolism and excretion from the body. A case of severe toxic liver injury.ĭescribed cases of toxic effects of Paralife, while the use of isoniazid. There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Paralife. When Paralife applied simultaneously with diazepam may decrease excretion of diazepam. With the simultaneous use of activated charcoal reduced bioavailability of Paralife. With the simultaneous use with urological means reduced their effectiveness. With the simultaneous use of oral contraceptives accelerated excretion of Paralife from the body and may reduce its analgesic action. With the simultaneous use of anticholinergics may decrease absorption of Paralife. With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time. With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Paralife. Used for treatment of premenstrual tension syndrome in combination with pamabrom and mepyramine (Histamine H1-receptors blocker). With prolonged use of Paralife is necessary to monitor patterns of peripheral blood and functional state of the liver. Paralife is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients. In experimental studies found no embryotoxic, teratogenic and mutagenic action of Paralife. If necessary, use of Paralife during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child. Paralife is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother. So far, no observed adverse effects of Paralife on the fetus in humans. Allergic reactions: rarely - skin rash, itching, hives.Ĭhronic active alcoholism, increased sensitivity to Paralife, marked disturbances of liver function and / or kidney disease, anemia, pregnancy. ![]() Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. The maximum duration of treatment - 3 days.ĭigestive system: rarely - dyspepsia long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. ![]() Multiplicity - 4 at intervals of not less than 4 h. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg. Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days. ![]() Fever in infectious and inflammatory diseases. Pain weak and moderate intensity of different genesis. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer. It has analgesic, antipyretic and weak anti-inflammatory action.
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